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Université d'Orléans

L'INEM publie sur les effets de l'ozone sur l'inflammation pulmonaire


URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016%2Fj.jaci.2017.11.044.

Nom du contact: Togbé Dieudonnée

Courriel du contact: dieudonnee.togbe@cnrs-orleans.fr

Lieu: INEM

Ozone exposure induces lung barrier biphasic injury and inflammation controlled by IL-33.

Michaudel C, Togbe D et al. J Allergy Clin Immunol. 2018 doi:10.1016/j.jaci.2017.11.044.

Environmental air pollution leads to the release of reactive oxygen in form of ozone, which causes irritation of the airways leading to chronic bronchitis and emphysema.

Tobge D and Michaudel C with the team investigate the effect of a single ozone exposure of mice (1ppm for 1h) and found a severe biphasic epithelial injury leading to acute inflammation and airway hyperreactivity, which is neutrophil and IL-33 dependent.

Future studies are ongoing to investigate the effect of chronic ozone exposure on chronic bronchitis and emphysema found in patients.