Université d'Orléans

Publications 2015

Chiazza F, Couturier-Maillard A, Benetti E, Mastrocola R, Nigro D, Cutrin JC, Serpe L, Aragno M, Fantozzi R, Ryffel B, Thiemermann C, Collino M.
Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice.
Mol Med ahead of print
pmid : 26623925


Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F.
Corrigendum: The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.
Nat. Immunol. 16:1292
pmid : 26580508


Chafai-Elalaoui S, Chalon M, Elkhartoufi N, Kriouele Y, Mansouri M, Attié-Bitach T, Sefiani A, Baala L.
A homozygous AHI1 gene mutation (p.Thr304AsnfsX6) in a consanguineous Moroccan family with Joubert syndrome: a case report.
J Med Case Rep 9:254
pmid : 26541515


Amaral FA, Bastos LF, Oliveira TH, Dias AC, Oliveira VL, Tavares LD, Costa VV, Galvão I, Soriani FM, Szymkowski DE, Ryffel B, Souza DG, Teixeira MM.
Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout.
Eur J Immunol ahead of print
pmid : 26449770


Hanot Mambres D, Machelart A, Vanderwinden JM, De Trez C, Ryffel B, Letesson JJ, Muraille E.
In Situ Characterization of Splenic Brucella melitensis Reservoir Cells during the Chronic Phase of Infection in Susceptible Mice.
PLoS ONE 10:e0137835
pmid : 26376185


Kiefer P, Schmitt U, Müller JE, Hartl J, Meyer F, Ryffel F, Vorholt JA.
DynaMet: a fully automated pipeline for dynamic LC-MS data.
Anal. Chem. 87:9679-86
pmid : 26366644


Alcocer-Gómez E, Ulecia-Morón C, Marín-Aguilar F, Rybkina T, Casas-Barquero N, Ruiz-Cabello J, Ryffel B, Apetoh L, Ghiringhelli F, Bullón P, Sánchez-Alcazar JA, Carrión AM, Cordero MD.
Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome.
Mol Neurobiol ahead of print
pmid : 26362308


Magnenat S, Ngo DT, Zünd F, Ryffel M, Noris G, Rothlin G, Marra A, Nitti M, Fua P, Gross M, Sumner RW.
Live texturing of augmented reality characters from colored drawings.
IEEE Trans Vis Comput Graph 21:1201-10
pmid : 26340776


Pinto LG, Talbot J, Peres RS, Franca RF, Ferreira SH, Ryffel B, Aves-Filho JC, Figueiredo F, Cunha TM, Cunha FQ.
Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production.
Arthritis Res. Ther. 17:235
pmid : 26330334


Rabeony H, Pohin M, Vasseur P, Petit-Paris I, Jégou JF, Favot L, Frouin E, Boutet MA, Blanchard F, Togbe D, Ryffel B, Bernard FX, Lecron JC, Morel F.
IMQ-induced skin inflammation in mice is dependent on IL-1R1 and MyD88 signaling but independent of the NLRP3 inflammasome.
Eur J Immunol ahead of print
pmid : 26147228


Bullon P, Alcocer-Gómez E, Carrión AM, Garrido-Maraver J, Marin-Aguilar F, Román-Malo L, Ruiz-Cabello J, Culic O, Ryffel B, Apetoh L, Ghiringhelli F, Battino M, Sánchez-Alcázar JA, Cordero MD.
AMPK phosphorylation modulates pain by activation of NLRP3-inflammasome.
Antioxid Redox Signal ahead of print
pmid : 26132721


Olleros ML, Chavez-Galan L, Segueni N, Bourigault ML, Vesin D, Kruglov AA, Drutskaya MS, Bisig R, Ehlers S, Aly S, Walter K, Kuprash DV, Chouchkova M, Kozlov SV, Erard F, Ryffel B, Quesniaux V, Nedospasov SA, Garcia I.
Control of Mycobacterial Infections in mice expressing human Tumor Necrosis Factor but not mouse TNF.
Infect Immun ahead of print
pmid : 26123801


Gicquel T, Robert S, Loyer P, Victoni T, Bodin A, Ribault C, Gleonnec F, Couillin I, Boichot E, Lagente V.
IL-1β production is dependent of the activation of purinergic receptors and NLRP3 pathway in human macrophages.
FASEB J ahead of print
pmid : 26116704


Francisco NM, Hsu NJ, Keeton R, Randall P, Sebesho B, Allie N, Govender D, Quesniaux V, Ryffel B, Kellaway L, Jacobs M.
TNF-dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis.
J Neuroinflammation 12:125
pmid : 26112704


Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F.
The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.
Nat Immunol ahead of print
pmid : 26098997


Cnops J, De Trez C, Bulte D, Radwanska M, Ryffel B, Magez S.
IFNγ mediates B cell loss in experimental African trypanosomosis.
Parasite Immunol ahead of print
pmid : 26079128


Hernández PP, Mahlakõiv T, Yang I, Schwierzeck V, Nguyen N, Guendel F, Gronke K, Ryffel B, Hölscher C, Dumoutier L, Renauld JC, Suerbaum S, Staeheli P, Diefenbach A.
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.
Nat. Immunol. 16:698-707
pmid : 26006013


Segueni N, Vigne S, Palmer G, Bourigault ML, Olleros ML, Vesin D, Garcia I, Ryffel B, Quesniaux VF, Gabay C.
Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection.
PLoS ONE 10:e0126058
pmid : 25950182


Santos-Durán GN, Menuet A, Lagadec R, Mayeur H, Ferreiro-Galve S, Mazan S, Rodríguez-Moldes I, Candal E.
Prosomeric organization of the hypothalamus in an elasmobranch, the catshark Scyliorhinus canicula.
Front Neuroanat 9:37
pmid : 25904850


Puget N, Leduc C, Oruc Z, Moutahir M, Le Bert M, Khamlichi AA.
Complete cis Exclusion upon Duplication of the Eμ Enhancer at the Immunoglobulin Heavy Chain Locus.
Mol. Cell. Biol. 35:2231-41
pmid : 25896912


Lagadec R, Laguerre L, Menuet A, Amara A, Rocancourt C, Péricard P, Godard BG, Rodicio MC, Rodriguez-Moldes I, Mayeur H, Rougemont Q, Mazan S, Boutet A.
The ancestral role of nodal signalling in breaking L/R symmetry in the vertebrate forebrain.
Nat Commun 6:6686
pmid : 25819227


Randall PJ, Hsu NJ, Quesniaux V, Ryffel B, Jacobs M.
Mycobacterium tuberculosis infection of the 'non-classical immune cell'.
Immunol Cell Biol ahead of print
pmid : 25801479


Madouri F, Guillou N, Fauconnier L, Marchiol T, Rouxel N, Chenuet P, Ledru A, Apetoh L, Ghiringhelli F, Chamaillard M, Zheng SG, Trovero F, Quesniaux VF, Ryffel B, Togbe D.
Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation.
J Mol Cell Biol ahead of print
pmid : 25714839


Lopes AH, Talbot J, Silva RL, Lima JB, França RO, Verri WA, Mascarenhas DP, Ryffel B, Cunha FQ, Zamboni DS, Cunha TM.
Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain.
Pain 156:451-9
pmid : 25687541


Palomo J, Reverchon F, Piotet J, Besnard AG, Couturier-Maillard A, Maillet I, Tefit M, Erard F, Mazier D, Ryffel B, Quesniaux VF.
Critical role of IL-33 receptor ST2 in experimental cerebral malaria development.
Eur. J. Immunol. 45:1354-65
pmid : 25682948


Marquet P, Longeray PH, Barlesi F, Ameye V, Augé P, Cazeneuve B, Chatelut E, Diaz I, Diviné M, Froguel P, Goni S, Gueyffier F, Hoog-Labouret N, Mourah S, Morin-Surroca M, Perche O, Perin-Dureau F, Pigeon M, Tisseau A, Verstuyft C.
Translational research: precision medicine, personalized medicine, targeted therapies: marketing or science?
Therapie 70:1-19
pmid : 25679189


Besnard AG, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw TN, Couper KN, Ryffel B, Liew FY.
IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.
PLoS Pathog. 11:e1004607
pmid : 25659095


Borges da Silva H, Fonseca R, Cassado Ados A, Machado de Salles É, de Menezes MN, Langhorne J, Perez KR, Cuccovia IM, Ryffel B, Barreto VM, Marinho CR, Boscardin SB, Álvarez JM, D'Império-Lima MR, Tadokoro CE.
In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria.
PLoS Pathog. 11:e1004598
pmid : 25658925


Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, Panek C, Le Bert M, Lagente V, Rassendren F, Riteau N, Couillin I.
The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine.
Cell Death Dis 6:e1629
pmid : 25654762


Rabolli V, Badissi AA, Devosse R, Uwambayinema F, Yakoub Y, Palmai-Pallag M, Lebrun A, De Gussem V, Couillin I, Ryffel B, Marbaix E, Lison D, Huaux F.
The alarmin IL-1α is a master cytokine in acute lung inflammation induced by silica micro- and nanoparticles.
Part Fibre Toxicol 11:69
pmid : 25497724


François A, Gombault A, Villeret B, Alsaleh G, Fanny M, Gasse P, Adam SM, Crestani B, Sibilia J, Schneider P, Bahram S, Quesniaux V, Ryffel B, Wachsmann D, Gottenberg JE, Couillin I.
B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis.
J. Autoimmun. 56:1-11
pmid : 25441030


Huaux F, Lo Re S, Giordano G, Uwambayinema F, Devosse R, Yakoub Y, Panin N, Palmai-Pallag M, Rabolli V, Delos M, Marbaix E, Dauguet N, Couillin I, Ryffel B, Renauld JC, Lison D.
IL-1α induces CD11b(low) alveolar macrophage proliferation and maturation during granuloma formation.
J. Pathol. 235:698-709
pmid : 25421226


Nascimento MS, Carregaro V, Lima-Júnior DS, Costa DL, Ryffel B, Duthie MS, de Jesus A, de Almeida RP, da Silva JS.
Interleukin 17A acts synergistically with interferon γ to promote protection against Leishmania infantum infection.
J. Infect. Dis. 211:1015-26
pmid : 25274569


Francisco NM, Hsu N-J, Keeton R, Randall PJ, Sebesho B, Allie N, Govender D, Quesniaux V, Ryffel B, Kellaway L, Jacobs M. (2015 in press)
TNF dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis.
J Neuroinflammation


Olleros ML, Chavez-Galan L, Segueni N, Bourigault ML, Vesin D, Kruglov AA, Drutskaya MS, Bisig R, Ehlers S, Aly S, Walter K, Kuprash DV, Chouchkova M, Kozlov SV, Erard F, Ryffel B, Quesniaux V, Nedospasov SA and Garcia I.
Control of Mycobacterial Infections in mice expressing human Tumor Necrosis Factor but not mouse TNF.
Infect. Immunity