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Texture Characterization of Bone radiograph images (TCB) is a challenge in the osteoporosis diagnosis to be held in conjunction and with the support of the International Society for Biomedical Imaging (ISBI) 2014.
Osteoporosis is defined as a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture . The most common method for osteoporosis diagnosis is to estimate Bone Mineral Density (BMD) by dual-energy X-ray absorptiometry . However, BMD alone represents only 60% of fracture prediction. The characterization of trabecular bone microarchitecture has been recognized as an important factor and completes the osteoporosis diagnosis using BMD , but it cannot be routinely obtained by noninvasive methods and requires a bone biopsy with histomorphometric analysis.
2D texture analysis offers a simple way to evaluate bone structure on conventional radiographs [2, 3]. Moreover, many studies have shown that 2D texture analysis can be considered as an indirect evaluation of 3D microarchitecture [4, 5, 6, 7, 8].
The evaluation of osteoporotic disease from bone radiograph images presents a major challenge for pattern recognition and medical applications. Textured images from the bone microarchitecture of osteoporotic and healthy subjects show a high degree of similarity, thus drastically increasing the difficulty of classifying such textures.
The goal of this Challenge is to identify osteoporotic cases from healthy controls on 2D bone radiograph images, using texture analysis. It consists of two populations composed of 87 control subjects (CT, Figure 1) and 87 patients with osteoporotic fractures (OP, Figure 2).
The Challenge is opened to academia and industry. Already published methods can also be submitted.
Some of the participants will be invited to present their work at the workshop during a half day session (28 April – 2 May, 2014) in the form of an oral or poster presentation.
The final results from this challenge will be summarized and submitted to a journal paper, presenting and comparing all used texture analysis methods used to achieve osteoporosis diagnosis on bone radiograph images. The journal paper will be written and co-authored by the organizers and the selected participants.
Figure 1: Control (CT) image Figure 2: Osteoporotic (OP) image
 R. Bartl, B. Frisch, Osteoporosis: Diagnosis, Prevention, Therapy, Second ed., Springer, 2009.
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 R. Jennane, R. Harba, G. Lemineur, S. Bretteil, A. Estrade, C. L. Benhamou, Estimation of the 3d self-similarity parameter of trabecular bone from its 2D projection. Med Image Analy., 11(1):91-98, 2007.
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 L. Pothuaud, P. Carceller, D. Hans, Correlations between grey-level variations in 2D projection images (TBS) and 3D microarchitecture: applications in the study of human trabecular bone microarchitecture. Bone 42(4):775–787, 2008.
 E. Lespessailles, C. Gadois, I. Kousignian, J. P. Neveu, P. Fardellone, S. Kolta, C. Roux, J. P. Do-Huu, C. L. Benhamou, Clinical interest of bone texture analysis in osteoporosis: a case control multicenter study. Osteoporos Internat., 19:1019-1028, 2008.