Université d'Orléans

Relations hôte-pathogènes - Collaborations

  • Laboratoire International Associé (LIA): TB Immunity - UCT, Cape Town, Afrique du Sud.

  • PICS (Projet International de Collaboration Scientifique) avec le Brésil
    « LUNG PATHOLOGIES » (2008-2010)
    avec les Departments of Pharmacology and Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Brésil

  • Divers partenariats et collaborations avec des compagnies biotech on pharmaceutiques, françaises et internationales

    Host response to mycobacteria

    1. Segueni N, Tritto E, Bourigault M-L, Rose S, Erard F, Le Bert M, Jacobs M, Di Padova F, Moulin P, Brees D, Chibout S-D, Ryffel B, Kammüller and Quesniaux VFJ. Controlled Mycobacterium tuberculosis infection under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNF neutralization Sci Rep 6:36923 (2016) IF: 5.23

    2. Benmerzoug S and Quesniaux VF. Bioengineered 3D Models for Studying Human Cell-Tuberculosis Interactions. Trends Microbiol. 2017 Apr;25(4):245-246. doi: 10.1016/ j.tim.2017.02.009. IF:12.3

    3. Hsu N-J, Fransisco NM, Keeton R, Allie N, Quesniaux VJF, Ryffel B, Jacobs M. Myeloid and T cell derived TNF protects against central nervous system tuberculosis. Frontiers Immunol Feb 23;8:180. doi: 10.3389/fimmu.2017.00180 (2017)

    4. Segueni N, Benmerzoug S, Rose S, Gauthier A, Bourigault ML, Reverchon F, Philippeau A, Erard F, Le Bert M, Bouscayrol H, Wachter T, Garcia I, Kollias G, Jacobs M, Ryffel B, Quesniaux VFJ. Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection. Sci Rep. 6:22454 (2016) IF: 5.23

    5. Dambuza IM, Keeton R, Hsu NJ, Allie N, Quesniaux VF, Ryffel B, Jacobs M. Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation. Sci Rep 2016 6:39499 (2016) doi: 10.1038/srep39499 IF: 5.23

    6. Chavez-Galan L, Vesin D, Segueni N, Prasad P, Buser-Llinares R, Blaser G, Pache JC, Ryffel B, Quesniaux VFJ, Garcia I. Tumor Necrosis Factor and Its Receptors Are Crucial to Control Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection in a Murine Model. Am J Pathol.186(9):2364-77 (2016) IF : 4,21

    7. Randall PJ, Hsu NJ, Quesniaux VFJ, Ryffel B, Jacobs M. Mycobacterium tuberculosis infection of the 'non-classical immune cell'. Immunol Cell Biol. 93(9):789-95 (2015) IF: 4.47

    8. Olleros ML, Chavez-Galan L, Segueni N, Bourigault ML, Vesin D, Kruglov AA, Drutskaya MS, Bisig R, Ehlers S, Aly S, Walter K, Kuprash DV, Chouchkova M, Kozlov SV, Erard F, Ryffel B, Quesniaux VFJ, Nedospasov SA and Garcia I. Control of Mycobacterial Infections in mice expressing human Tumor Necrosis Factor but not mouse TNF. Infect. Immunity. 83(9):3612-23 (2015) IF: 3.61

    9. Francisco NM, Hsu NJ, Keeton R, Randall PJ, Sebesho B, Allie N, Govender D, Quesniaux VFJ, Ryffel B, Kellaway L, Jacobs M. TNF dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis. J Neuroinflam. 12:125 (2015) IF: 4.67

    10. Segueni N, Vigne S, Palmer G, Bourigault ML, Olleros ML, Vesin D, Garcia I, Ryffel B, Quesniaux VFJ*, Gabay C*. Limited contribution of IL-36 versus IL-1 and TNF pathways in host response to mycobacterial infection. PLoS One. 10(5):e0126058 (2015) * equal contribution of the last authors IF: 3.06

    11. Randall PJ, Hsu NJ, Lang D, Cooper S, Sebesho B, Allie N, Keeton R, Francisco NM, Salie S, Labuschagné A, Quesniaux VFJ, Ryffel B, Kellaway L, Jacobs M. Neurons are host cells for Mycobacterium tuberculosis. Infect Immun. 82(5):1880-90 (2014) IF: 3.73

    12. Keeton R, Allie N, Dambuza I, Abel B, Hsu NJ, Sebesho B, Randall P, Burger P, Fick E, Quesniaux VFJ, Ryffel B and Jacobs M. Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis. J Clin Invest. 124(4):1537-51 (2014) IF: 13.26

    13. Almeida PE, Roque NR, Magalhães KG, Mattos KA, Teixeira L, Maya-Monteiro C, Almeida CJ, Castro-Faria-Neto HC, Ryffel B, Quesniaux VFJ, Bozza PT. Differential TLR2 downstream signaling regulates lipid metabolism and cytokine production triggered by Mycobacterium bovis BCG infection. Biochim Biophys Acta. 1841(1):97-107 (2014) IF: 5.16

    14. Bourigault ML, Segueni N, Rose S, Court N, Vacher R, Vasseur V, Erard F, Le Bert M, Garcia I, Iwakura Y, Jacobs M, Ryffel B and Quesniaux VFJ. Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG. Immunity, Inflammation & Disease. 1(1):47-62 (2013)

    15. Allie N, Grivennikov SI, Keeton R, Hsu NJ, Bourigault ML, Court N, Fremond C, Yeremeev V, Shebzukhov Y, Ryffel B, Nedospasov SA*, Quesniaux VFJ* & Jacobs M*. Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection. Sci Rep. 3:1809 (2013) * equal contribution of the last authors. IF: 7.12

    16. Bourigault ML, Vacher R, Rose S, Olleros ML, Janssens JP, Ryffel B, Quesniaux VFJ and Garcia I. Tumor necrosis factor neutralization combined with chemotherapy enhances Mycobacterium tuberculosis clearance and reduces lung pathology. Am J Clin Exp Immunol. 2(1):124-34 (2013) IF: 3.15

    17. Front S, Bourigault ML, Rose S, Segueni N, Quesniaux VFJ and Martin OR. Synthesis and biological investigation of PIM mimics carrying biotin or a fluorescent label for cellular imaging. Bioconjugate Chem. 24(1):72-84 (2013) IF: 4.82

    18. Chapman R, Shephard E, Stutz H, Douglass N, Sambandamurthy V, Garcia I, Ryffel B, Jacobs W, Williamson AL. Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. PLoS One. 7(3):e32769 (2012) IF: 3.73

    19. Sorgi CA, Rose S, Court N, Carlos D, Paula-Silva FW, Assis PA, Frantz FG, Ryffel B, Quesniaux VFJ, Faccioli LH. GM-CSF Priming Drives Bone Marrow-Derived Macrophages to a Pro-Inflammatory Pattern and Downmodulates PGE(2) in Response to TLR2 Ligands. PLoS One. 7(7):e40523 (2012) IF: 3.73

    20. Dambuza I , Keeton R , Allie N , Hsu NJ , Randall P , Sebesho B, Fick L, Quesniaux VFJ, Jacobs M. Reactivation of M. tuberculosis infection in trans-membrane Tumour Necrosis Factor mice. PLoS One. 6(11):e25121 (2011) IF: 4.09

    21. Court N, Rose S, Bourigault ML, Front S, Martin OR, Dowling JK, Kenny EF, O’Neill L, Erard F and Quesniaux VFJ. Mycobacterial PIMs inhibit host inflammatory responses through CD14-dependent and CD14-independent mechanisms. PLoS One. 6(9):e24631 (2011) IF: 4.09

    22. Garcia I, Olleros ML, Quesniaux VFJ, Jacobs M, Allie N, Nedospasov SA, Szymkowski DE, Ryffel B. Roles of Soluble and Membrane TNF and Related Ligands in Mycobacterial Infections: Effects of Selective and Non-selective TNF Inhibitors During Infection. Adv Exp Med Biol. 691:187-201 (2011) IF: 1.1

    23. Front S, Court N, Bourigault ML, Rose S, Ryffel B, Erard F, Quesniaux VFJ and Martin OR. Phosphatidyl myo-inositol mannosides mimics built on an acyclic or heterocyclic core: synthesis and anti-inflammatory properties. Chem. Med. Chem. 6(11):2081-93 (2011) IF: 3.15


    Immune responses in cerebral malaria

    1. Reverchon F, Mortaud S, Sivoyon M, Maillet I, Laugeray A, Palomo J, Montécot C, Herzine A, Meme S, Meme W, Erard F, Ryffel B, Menuet A and Quesniaux VFJ. IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria. PLoS Path Apr 27;13:e1006322 (2017) IF: 7.64

    2. Palomo J, Reverchon F, Piotet J, Besnard AG, Couturier-Maillard A, Maillet I, Tefit M, Erard F, Mazier D, Ryffel B and Quesniaux VFJ. Critical role of IL-33 receptor ST2 in experimental cerebral malaria development. Eur J Immunol. 45(5):1354-65 (2015) IF: 4.18

    3. Besnard AG, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw TN, Couper KN, Ryffel B and Liew FY. IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS Pathog. 11:e1004607 (2015) IF: 7.01

    4. Borges da Silva H, Fonseca R, Cassado Ados A, Machado de Salles É, de Menezes MN, Langhorne J, Perez KR, Cuccovia IM, Ryffel B, Barreto VM, Marinho CR, Boscardin SB, Álvarez JM, D'Império-Lima MR, Tadokoro CE. In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria. PLoS Pathog. 11:e1004598 (2015) IF: 7.01

    5. Palomo J, Fauconnier M, Coquard L, Gilles M, Meme S, Szeremeta F, Fick L, Franetich JF, Jacobs M, Togbe D, Beloeil JC, Mazier D, Ryffel B and Quesniaux VFJ. Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. Eur J Immunol. 43(10):2683-95 (2013) IF: 4.52

    6. Fauconnier M, Palomo J, Bourigault ML, Meme S, Szemeta F, Beloeil JC, Danneels A, Charron S, Rihet P, Ryffel B, and Quesniaux VFJ. IL-12Rβ2 is essential for development of experimental cerebral malaria. J. Immunol. 188(4):1905-14 (2012) IF: 5.52

    7. Lacerda-Queiroz N, Rodrigues DH, Vilela MC, Rachid MA, Soriani FM, Sousa LP, Campos RD, Quesniaux VFJ, Teixeira MM, Teixeira AL. Platelet-Activating Factor Receptor Is Essential for the Development of Experimental Cerebral Malaria. Am J Pathol. 180(1):246-55 (2012) IF: 4.52

    8. Fauconnier M, Bourigault ML, Meme S, Szemeta F, Danneels A, Charron S, Fick L, Jacobs M, Beloeil JC, Ryffel B, and Quesniaux VFJ. Protein kinase C-theta is required for the development of experimental cerebral malaria. Am J Pathol. 178(1):212-21 (2011) IF: 4.89