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Publications Allergie, infection respiratoire et immunité

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 Publications allergie, infection respiratoire et immunité depuis 2011

Asthma

Chung KF, Togbe D, Ryffel B. Editorial: Ozone as a Driver of Lung Inflammation and Innate Immunity and as a Model for Lung Disease. Front Immunol. 2021;12:714161. IF: 5.08

Nehmar R, Fauconnier L, Alves-Filho J, Togbe D, DeCauwer A, Bahram S, et al. Aryl hydrocarbon receptor (Ahr)-dependent Il-22 expression by type 3 innate lymphoid cells control of acute joint inflammation. J Cell Mol Med. 2021;25(10):4721-31. IF: 5.31

Ait Yahia S, Audousset C, Alvarez-Simon D, Vorng H, Togbe D, Marquillies P, Delacre M, Rose S, Bouscayrol H, Rifflet A, Quesniaux V, Boneca IG, Chamaillard M, Tsicopoulos A. NOD1 sensing of house dust mite-derived microbiota promotes allergic experimental asthma. J Allergy Clin Immunol. 2021 Jan 25: S0091-6749(21)00093-2. doi: 10.1016/j.jaci.2020.12.649. Online ahead of print. PMID: 33508265. IF: 14.11

Dalloul Z, Best M, Chenuet P, Dalloul I, Le Noir S, Togbe D, et al. Bromodomain and extraterminal (BET) protein inhibition of IgG/IgE production in murine B cells is counter-balanced by a strong Th2 bias. Clin Transl Immunology. 2021;10(6):e1280. IF: 5.03

Togbe D, Benmerzoug S, Jacobs M, Ryffel B and Quesniaux VFJ. Silica-related diseases in the modern world: a role for self-DNA sensing in lung inflammatory diseases. Allergy, 75:3009-10 (2020). doi: 10.1111/all.14463. PMID: 33155702 (2020) hal + doc IF:8.7

Darby M, Roberts LB, Mackowiak C, Chetty A, Tinelli S, Schnoeller C, Quesniaux V, Berrard S, Togbe D, Selkirk ME, Ryffel B, Horsnell WGC. ILC3-derived acetylcholine promotes protease-driven allergic lung pathology. J Allergy Clin Immunol. 19: S0091-6749(20)31586-4 (2020). doi: 10.1016/j.jaci.2020.10.038. PMID: 33461747. IF: 14.11

Michaudel C, Bataille F, Maillet I, Fauconnier L, Colas C, Sokol H, Straube M, Couturier-Maillard A, Dumoutier L, van Snick J, Quesniaux VF, Togbe D, Ryffel B. Ozone-Induced Aryl Hydrocarbon Receptor Activation Controls Lung Inflammation via Interleukin-22 Modulation. Front Immunol. 2020 Feb 25;11: 144. doi: 10.3389/fimmu.2020.00144. PMID: 32161582. IF: 5.08

Wiegman CH, Li F, Ryffel B, Togbe D, Chung KF. Oxidative Stress in Ozone-Induced Chronic Lung Inflammation and Emphysema: A Facet of Chronic Obstructive Pulmonary Disease. Front Immunol. 11:1957 (2020). doi: 10.3389/fimmu.2020.01957. IF: 5.08

Floris I, Chenuet P, Togbe D, Volteau C, Lejeune B. Potential Role of the Micro-Immunotherapy Medicine 2LALERG in the Treatment of Pollen-Induced Allergic Inflammation. Dose Response. 2020;18(1):1559325820914092. IF: 3.21

Sokolowska M, Quesniaux VFJ, Akdis CA, Chung KF, Ryffel B, and Togbe D. Acute respiratory barrier disruption by ozone exposure in mice. Front Immunol 10:2169 (2019) hal-02354637 + doc. IF:5.08

Michaudel C, Mackowiak Claire, Maillet I, Fauconnier L, Akdis C, Sokolowska M, Dreher A, Tan H-T.T., Quesniaux V.F., Ryffel B and Togbe D. Ozone exposure induces respiratory barrier biphasic injury and inflammation controlled by Interleukin-33 J Allergy Clin Immun 142:942-958 (2018). doi: 10.1016/j.jaci.2017.11.044. PMID:29331644 hal-02126403. IF:14.11

Dalloul Z, Chenuet P, Dalloul I, Boyer F, Aldigier JC, Laffleur B, El Makhour Y, Ryffel B, Quesniaux VFJ, Togbe D, Mergny JL, Cook-Moreau J and Cogné M. G-quadruplex DNA targeting alters class switch recombination in B cells and attenuates allergic inflammation. J Allergy Clin Immun 142:1352-1355 (2018) doi: 10.1016/j.jaci.2018.06.011 hal-02179335. IF:14.11

Madouri, F., Chenuet P, Beuraud C, Fauconnier L, Marchiol T, Rouxel N, Ledru A, Gallerand M, Lombardi V, Mascarell L, Marquant Q, Apetoh L, Erard F, Le Bert M, Trovero F, Quesniaux VF, Ryffel B, Togbe D. PKC theta controls ILC2 and Th2 responses to house dust mite allergen. J Allergy Clin Immun 139:1650-66 (2017). doi: 10.1016/j.jaci.2016.08.044 PMID:27746240. hal-01512634. IF : 14.11

Mascarell L, Airouche S, Berjont N, Gary C, Gueguen C, Fourcade G, Bellier B, Togbe D, Ryffel B, Klatzmann D, Baron-Bodo V, Moingeon P. The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation. Mucosal Immunol. 2017 May; 10:695-704. doi: 10.1038/mi.2016.87. hal-02126459. IF: 6.72

Chenuet P, Fauconnier L, Madouri F, Marchiol T, Rouxel N, Ledru A, Mauny P, Lory R, Uttenhove C, van Snick J, Iwakura Y, di Padova F, Quesniaux V, Togbe D, Ryffel B. Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice. Clin Sci (Lond). 2017 131:2533-2548. IF:5.12

Bruchard M, Rebé C, Derangère V, Togbe D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F. The receptor NLRP3 is a transcriptional regulator of T(H)2 differentiation. Nat Immunol. 16:859-70 (2015) PMID: 26098997. IF:20.47

Madouri F, Guillou N, Fauconnier L, Marchiol T, Rouxel N, Chenuet P, Ledru A, Apetoh L, Ghiringhelli F, Chamaillard M, Zheng SG, Trovero F, Quesniaux VFJ, Ryffel B and Togbe D. Caspase-1 activation by NLRP3 inflammasome dampens IL-33 dependent house dust mite induced allergic lung inflammation. J Mol Cell Biol 7:351-65 (2015). IF: 8.81

Besnard A-G, Togbe D, Couillin I, Tan Z, Zheng S-G, Erard F, Le Bert M, Quesniaux V and Ryffel B. Inflammasome – IL-1 – Th17 response in allergic lung inflammation J Mol Cell Biol. 4:3-10 (2012). IF: 8.81

Besnard A-G, Sabat R, Dumoutier L, Renaud JC, Willart M, Lambrecht B, Teixeira MM, Charon S, Fick L, Erard F, Warszawska K, Wolk K, Quesniaux V, Ryffel B and Togbe D. Dual role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A. Am J Respir Crit Care Med. 183 :1153-63 (2011). IF: 21.40

Besnard A-G, Guillou N, Tschopp J, Erard F, Couillin I, Iwakura Y, Quesniaux V, Ryffel B and Togbe D. NLRP3 inflammasome is required in murine asthma in absence of aluminium adjuvant. Allergy 66:1047-57 (2011). IF: 13.14

Besnard A-G, Togbe D, Guillou N, Erard F, Quesniaux V and Ryffel B. IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur J Immunol 41:1675-86 (2011). IF: 5.53

 

Microbiote

Ferrere G, Tidjani Alou M, Liu P, Goubet AG, Fidelle M, Kepp O, Durand S, Iebba V, Fluckiger A, Daillère R, Thelemaque C, Grajeda-Iglesias C, Alves Costa Silva C, Aprahamian F, Lefevre D, Zhao L, Ryffel B, Colomba E, Arnedos M, Drubay D, Rauber C, Raoult D, Asnicar F, Spector T, Segata N, Derosa L, Kroemer G, Zitvogel L. Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade. JCI Insight. 2021 Jan 25;6(2) :e145207. doi: 10.1172/jci.insight.145207. PMID: 33320838. IF: 8.31

Di Domizio J, Belkhodja C, Chenuet P, Fries A, Murray T, Mondéjar PM, Demaria O, Conrad C, Homey B, Werner S, Speiser DE, Ryffel B, Gilliet M. The commensal skin microbiota triggers type I IFN-dependent innate repair responses in injured skin. Nat Immunol. 2020 Sep;21(9):1034-1045. doi: 10.1038/s41590-020-0721-6. PMID: 32661363. IF:20.47

Roberti MP, Yonekura S, Duong CPM, Picard M, Ferrere G, Tidjani Alou M, Rauber C, Iebba V, Lehmann CHK, Amon L, Dudziak D, Derosa L, Routy B, Flament C, Richard C, Daillère R, Fluckiger A, Van Seuningen I, Chamaillard M, Vincent A, Kourula S, Opolon P, Ly P, Pizzato E, Becharef S, Paillet J, Klein C, Marliot F, Pietrantonio F, Benoist S, Scoazec JY, Dartigues P, Hollebecque A, Malka D, Pagès F, Galon J, Gomperts Boneca I, Lepage P, Ryffel B, Raoult D, Eggermont A, Vanden Berghe T, Ghiringhelli F, Vandenabeele P, Kroemer G, Zitvogel L. Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer. Nat Med. 2020 Jun;26(6):919-931. doi: 10.1038/s41591-020-0882-8. PMID: 32451498. IF:36.13

Hrdý J, Alard J, Couturier-Maillard A, Boulard O, Boutillier D, Delacre M, Lapadatescu C, Cesaro A, Blanc P, Pot B, Ryffel B, Chamaillard M, Grangette C. Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses. Sci Rep. 2020 Mar 24;10(1):5345. doi: 10.1038/s41598-020-62161-1. PMID: 32210304. IF:3.99

Legoux F, Bellet D, Daviaud C, El Morr Y, Darbois A, Niort K, Procopio E, Salou M, Gilet J, Ryffel B, Balvay A, Foussier A, Sarkis M, El Marjou A, Schmidt F, Rabot S, Lantz O. Microbial metabolites control the thymic development of mucosal-associated invariant T cells. Science. 2019 Oct 25;366(6464):494-499. doi: 10.1126/science. aaw2719. PMID: 31467190. IF:41.84

Ryffel B, Huang F, Robinet P, Panek C, Couillin I, Erard F, Piotet J, Le Bert M, Mackowiak C, Torres Arias M, Dimier-Poisson I, Zheng SG. Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression. Front Immunol. 2019 Apr 18;10:702. doi: 10.3389/fimmu.2019.00702. PMID: 31057534. IF:5.08

Mauras A, Chain F, Faucheux A, Ruffié P, Gontier S, Ryffel B, Butel MJ, Langella P, Bermúdez-Humarán LG, Waligora-Dupriet AJ. A New Bifidobacteria Expression SysTem (BEST) to Produce and Deliver Interleukin-10 in Bifidobacterium bifidum. Front Microbiol. 2018 Dec 21;9:3075. doi: 10.3389/fmicb.2018.03075. PMID: 30622516. IF:4.07

Normand S, Waldschmitt N, Neerincx A, Martinez-Torres RJ, Chauvin C, Couturier-Maillard A, Boulard O, Cobret L, Awad F, Huot L, Ribeiro-Ribeiro A, Lautz K, Ruez R, Delacre M, Bondu C, Guilliams M, Scott C, Segal A, Amselem S, Hot D, Karabina S, Bohn E, Ryffel B, Poulin LF, Kufer TA, Chamaillard M. Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Nat Commun. 2018 Dec 17;9(1):5338. doi: 10.1038/s41467-018-07750-5. PMID: 30559449. IF:14.91

Couturier-Maillard A, Froux N, Piotet-Morin J, Michaudel C, Brault L, Le Bérichel J, Sénéchal A, Robinet P, Chenuet P, Jejou S, Dumoutier L, Renauld JC, Iovanna J, Huber S, Chamaillard M, Quesniaux VFJ, Sokol H, Ryffel B. Correction: Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation. Mucosal Immunol. 2019 Jan;12(1):290. doi: 10.1038/s41385-018-0112-6. PMID: 30504789. IF:7.37

Pérez MM, Martins LMS, Dias MS, Pereira CA, Leite JA, Gonçalves ECS, de Almeida PZ, de Freitas EN, Tostes RC, Ramos SG, de Zoete MR, Ryffel B, Silva JS, Carlos D. Interleukin-17/interleukin-17 receptor axis elicits intestinal neutrophil migration, restrains gut dysbiosis and lipopolysaccharide translocation in high-fat diet-induced metabolic syndrome model. Immunology. 2019 Apr;156(4):339-355. doi: 10.1111/imm.13028. PMID: 30472727. IF:7.39

Waldschmitt N, Kitamoto S, Secher T, Zacharioudaki V, Boulard O, Floquet E, Delacre M, Lamas B, Pham HP, Six A, Richard ML, Dagorn JC, Eberl G, Langella P, Chatel JM, Ryffel B, Iovanna JL, Poulin LF, Sokol H, Kamada N, Chamaillard M. The regenerating family member 3 beta instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure. Gut. 2019 Jul;68(7):1190-1199. doi: 10.1136/gutjnl-2018-316757. PMID: 30279238. IF: 19.81

Miani M, Le Naour J, Waeckel-Enée E, Verma SC, Straube M, Emond P, Ryffel B, van Endert P, Sokol H, Diana J. Gut Microbiota-Stimulated Innate Lymphoid Cells Support beta-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes. Cell Metab. 2018 Oct 2;28(4):557-572.e6. doi: 10.1016/j.cmet.2018.06.012. PMID: 30017352. IF : 21.56

Couturier-Maillard A, Froux N, Piotet-Morin J, Michaudel C, Brault L, Le Bérichel J, Sénéchal A, Robinet P, Chenuet P, Jejou S, Dumoutier L, Renauld JC, Iovanna J, Huber S, Chamaillard M, Quesniaux V, Sokol H, Chamaillard M, Ryffel B. Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation. Mucosal Immunol. 2018 Jul;11(4):1181-1190. doi: 10.1038/s41385-018-0005-8. PMID: 29728643. IF:7.37

Martins LMS, Perez MM, Pereira CA, Costa FRC, Dias MS, Tostes RC, Ramos SG, de Zoete MR, Ryffel B, Silva JS, Carlos D. Interleukin-23 promotes intestinal T helper type17 immunity and ameliorates obesity-associated metabolic syndrome in a murine high-fat diet model. Immunology. 2018 May 2;154(4):624-36. doi: 10.1111/imm.12946. PMID: 29722014. IF:7.39

Radulovic K, Normand S, Rehman A, Delanoye-Crespin A, Chatagnon J, Delacre M, Waldschmitt N, Poulin LF, Iovanna J, Ryffel B, Rosenstiel P, Chamaillard M. A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation. Mucosal Immunol. 2018 May;11(3):811-819. doi: 10.1038/mi.2017.87. PMID: 29139477. IF:7.37

Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 2018 Jan 5;359(6371):91-97. doi: 10.1126/science. aan3706. PMID: 29097494. IF:41.84

Lamas B, Richard ML, Leducq V, Pham HP, Michel ML, Da Costa G, Bridonneau C, Jegou S, Hoffmann TW, Natividad JM, Brot L, Taleb S, Couturier-Maillard A, Nion-Larmurier I, Merabtene F, Seksik P, Bourrier A, Cosnes J, Ryffel B, Beaugerie L, Launay JM, Langella P, Xavier RJ, Sokol H. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands. Nat Med. 2016 Jun;22(6):598-605. doi: 10.1038/nm.4102. PMID: 27158904. IF:36.13

Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, Schlitzer A, Ginhoux F, Apetoh L, Chachaty E, Woerther PL, Eberl G, Bérard M, Ecobichon C, Clermont D, Bizet C, Gaboriau-Routhiau V, Cerf-Bensussan N, Opolon P, Yessaad N, Vivier E, Ryffel B, Elson CO, Doré J, Kroemer G, Lepage P, Boneca IG, Ghiringhelli F, Zitvogel L. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013 Nov 22;342(6161):971-6. doi: 10.1126/science.1240537. PMID: 24264990. IF:41.84

Couturier-Maillard A, Secher T, Rehman A, Normand S, De Arcangelis A, Haesler R, Huot L, Grandjean T, Bressenot A, Delanoye-Crespin A, Gaillot O, Schreiber S, Lemoine Y, Ryffel B, Hot D, Nùñez G, Chen G, Rosenstiel P, Chamaillard M. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J Clin Invest. 2013 Feb;123(2):700-11. doi: 10.1172/JCI62236. Epub 2013 Jan 2. PMID: 23281400. IF:14.80

Dessein R, Gironella M, Vignal C, Peyrin-Biroulet L, Sokol H, Secher T, Lacas-Gervais S, Gratadoux JJ, Lafont F, Dagorn JC, Ryffel B, Akira S, Langella P, Nùñez G, Sirard JC, Iovanna J, Simonet M, Chamaillard M. Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis. Gut. 2009 Jun;58(6):771-6. doi: 10.1136/gut.2008.168443. Epub 2009 Jan 27. PMID: 19174417. IF: 19.81

 

Host response to mycobacteria

Benmerzoug S, Rose S, Bounab B, Gosset D, Duneau L, Chenuet P, Mollet L, Le Bert M, Lambers C, Geleff S, Roth M, Fauconnier L, Sedda D, Carvalho C, Perche O, Laurenceau D, Ryffel B, Apetoh L, Kiziltunc A, Uslu H, Sultan Albez F, Akgun M, Togbe D* and Quesniaux VFJ*. STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nature Communications 9:5226 (2018) doi: 10.1038/s41467-018-07425-1 IF: 12.35

Segueni N, Tritto E, Bourigault M-L, Rose S, Erard F, Le Bert M, Jacobs M, Di Padova F, Moulin P, Brees D, Chibout S-D, Ryffel B, Kammüller and Quesniaux VFJ. Controlled Mycobacterium tuberculosis infection under treatment with anti-IL-17A or IL-17F antibodies, in contrast to TNF neutralization Sci Rep 6:36923 (2016) IF: 5.23

Benmerzoug S and Quesniaux VF. Bioengineered 3D Models for Studying Human Cell-Tuberculosis Interactions. Trends Microbiol. 2017 Apr;25(4):245-246. doi: 10.1016/ j.tim.2017.02.009. IF:12.3

 Hsu N-J, Fransisco NM, Keeton R, Allie N, Quesniaux VJF, Ryffel B, Jacobs M. Myeloid and T cell derived TNF protects against central nervous system tuberculosis. Frontiers Immunol Feb 23;8:180. doi: 10.3389/fimmu.2017.00180 (2017)

Segueni N, Benmerzoug S, Rose S, Gauthier A, Bourigault ML, Reverchon F, Philippeau A, Erard F, Le Bert M, Bouscayrol H, Wachter T, Garcia I, Kollias G, Jacobs M, Ryffel B, Quesniaux VFJ. Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection. Sci Rep. 6:22454 (2016) IF: 5.23

Dambuza IM, Keeton R, Hsu NJ, Allie N, Quesniaux VF, Ryffel B, Jacobs M. Persistent p55TNFR expression impairs T cell responses during chronic tuberculosis and promotes reactivation. Sci Rep 2016 6:39499 (2016) doi: 10.1038/srep39499 IF: 5.23

Chavez-Galan L, Vesin D, Segueni N, Prasad P, Buser-Llinares R, Blaser G, Pache JC, Ryffel B, Quesniaux VFJ, Garcia I. Tumor Necrosis Factor and Its Receptors Are Crucial to Control Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection in a Murine Model. Am J Pathol.186(9):2364-77 (2016) IF: 4,21

 Randall PJ, Hsu NJ, Quesniaux VFJ, Ryffel B, Jacobs M. Mycobacterium tuberculosis infection of the 'non-classical immune cell'. Immunol Cell Biol. 93(9):789-95 (2015) IF: 4.47

 Olleros ML, Chavez-Galan L, Segueni N, Bourigault ML, Vesin D, Kruglov AA, Drutskaya MS, Bisig R, Ehlers S, Aly S, Walter K, Kuprash DV, Chouchkova M, Kozlov SV, Erard F, Ryffel B, Quesniaux VFJ, Nedospasov SA and Garcia I. Control of Mycobacterial Infections in mice expressing human Tumor Necrosis Factor but not mouse TNF. Infect. Immunity. 83(9):3612-23 (2015) IF: 3.61

 Francisco NM, Hsu NJ, Keeton R, Randall PJ, Sebesho B, Allie N, Govender D, Quesniaux VFJ, Ryffel B, Kellaway L, Jacobs M. TNF dependent regulation and activation of innate immune cells are essential for host protection against cerebral tuberculosis. J Neuroinflam. 12:125 (2015) IF: 4.67

 Segueni N, Vigne S, Palmer G, Bourigault ML, Olleros ML, Vesin D, Garcia I, Ryffel B, Quesniaux VFJ*, Gabay C*. Limited contribution of IL-36 versus IL-1 and TNF pathways in host response to mycobacterial infection. PLoS One. 10(5): e0126058 (2015) * equal contribution of the last authors IF: 3.06

Randall PJ, Hsu NJ, Lang D, Cooper S, Sebesho B, Allie N, Keeton R, Francisco NM, Salie S, Labuschagné A, Quesniaux VFJ, Ryffel B, Kellaway L, Jacobs M. Neurons are host cells for Mycobacterium tuberculosis. Infect Immun. 82(5):1880-90 (2014) IF: 3.73

Keeton R, Allie N, Dambuza I, Abel B, Hsu NJ, Sebesho B, Randall P, Burger P, Fick E, Quesniaux VFJ, Ryffel B and Jacobs M. Soluble TNFRp75 regulates host protective immunity against Mycobacterium tuberculosis. J Clin Invest. 124(4):1537-51 (2014) IF: 13.26

Almeida PE, Roque NR, Magalhães KG, Mattos KA, Teixeira L, Maya-Monteiro C, Almeida CJ, Castro-Faria-Neto HC, Ryffel B, Quesniaux VFJ, Bozza PT. Differential TLR2 downstream signaling regulates lipid metabolism and cytokine production triggered by Mycobacterium bovis BCG infection. Biochim Biophys Acta. 1841(1):97-107 (2014) IF: 5.16

Bourigault ML, Segueni N, Rose S, Court N, Vacher R, Vasseur V, Erard F, Le Bert M, Garcia I, Iwakura Y, Jacobs M, Ryffel B and Quesniaux VFJ. Relative contribution of IL-1α, IL-1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG. Immunity, Inflammation & Disease. 1(1):47-62 (2013)

Allie N, Grivennikov SI, Keeton R, Hsu NJ, Bourigault ML, Court N, Fremond C, Yeremeev V, Shebzukhov Y, Ryffel B, Nedospasov SA*, Quesniaux VFJ* & Jacobs M*. Prominent role for T cell-derived Tumour Necrosis Factor for sustained control of Mycobacterium tuberculosis infection. Sci Rep. 3:1809 (2013) * equal contribution of the last authors. IF: 7.12

Bourigault ML, Vacher R, Rose S, Olleros ML, Janssens JP, Ryffel B, Quesniaux VFJ and Garcia I. Tumor necrosis factor neutralization combined with chemotherapy enhances Mycobacterium tuberculosis clearance and reduces lung pathology. Am J Clin Exp Immunol. 2(1):124-34 (2013) IF: 3.15

Front S, Bourigault ML, Rose S, Segueni N, Quesniaux VFJ and Martin OR. Synthesis and biological investigation of PIM mimics carrying biotin or a fluorescent label for cellular imaging. Bioconjugate Chem. 24(1):72-84 (2013) IF: 4.82

Chapman R, Shephard E, Stutz H, Douglass N, Sambandamurthy V, Garcia I, Ryffel B, Jacobs W, Williamson AL. Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells. PLoS One. 7(3): e32769 (2012) IF: 3.73

Sorgi CA, Rose S, Court N, Carlos D, Paula-Silva FW, Assis PA, Frantz FG, Ryffel B, Quesniaux VFJ, Faccioli LH. GM-CSF Priming Drives Bone Marrow-Derived Macrophages to a Pro-Inflammatory Pattern and Downmodulates PGE (2) in Response to TLR2 Ligands. PLoS One. 7(7): e40523 (2012) IF: 3.73

Dambuza I, Keeton R, Allie N, Hsu NJ, Randall P, Sebesho B, Fick L, Quesniaux VFJ, Jacobs M. Reactivation of M. tuberculosis infection in trans-membrane Tumour Necrosis Factor mice. PLoS One. 6(11): e25121 (2011) IF: 4.09

Court N, Rose S, Bourigault ML, Front S, Martin OR, Dowling JK, Kenny EF, O’Neill L, Erard F and Quesniaux VFJ. Mycobacterial PIMs inhibit host inflammatory responses through CD14-dependent and CD14-independent mechanisms. PLoS One. 6(9): e24631 (2011) IF: 4.09

Garcia I, Olleros ML, Quesniaux VFJ, Jacobs M, Allie N, Nedospasov SA, Szymkowski DE, Ryffel B. Roles of Soluble and Membrane TNF and Related Ligands in Mycobacterial Infections: Effects of Selective and Non-selective TNF Inhibitors During Infection. Adv Exp Med Biol. 691:187-201 (2011) IF: 1.1

Front S, Court N, Bourigault ML, Rose S, Ryffel B, Erard F, Quesniaux VFJ and Martin OR. Phosphatidyl myo-inositol mannosides mimics built on an acyclic or heterocyclic core: synthesis and anti-inflammatory properties. Chem. Med. Chem. 6(11):2081-93 (2011) IF: 3.15

 
Immune responses in cerebral malaria

Reverchon F, Mortaud S, Sivoyon M, Maillet I, Laugeray A, Palomo J, Montécot C, Herzine A, Meme S, Meme W, Erard F, Ryffel B, Menuet A and Quesniaux VFJ. IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria. PLoS Path Apr 27;13: e1006322 (2017) IF: 7.64

Palomo J, Reverchon F, Piotet J, Besnard AG, Couturier-Maillard A, Maillet I, Tefit M, Erard F, Mazier D, Ryffel B and Quesniaux VFJ. Critical role of IL-33 receptor ST2 in experimental cerebral malaria development. Eur J Immunol. 45(5):1354-65 (2015) IF: 4.18

Besnard AG, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw TN, Couper KN, Ryffel B and Liew FY. IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells. PLoS Pathog. 11:e1004607 (2015) IF: 7.01

Borges da Silva H, Fonseca R, Cassado Ados A, Machado de Salles É, de Menezes MN, Langhorne J, Perez KR, Cuccovia IM, Ryffel B, Barreto VM, Marinho CR, Boscardin SB, Álvarez JM, D'Império-Lima MR, Tadokoro CE. In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria. PLoS Pathog. 11: e1004598 (2015) IF: 7.01

Palomo J, Fauconnier M, Coquard L, Gilles M, Meme S, Szeremeta F, Fick L, Franetich JF, Jacobs M, Togbe D, Beloeil JC, Mazier D, Ryffel B and Quesniaux VFJ. Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA. Eur J Immunol. 43(10):2683-95 (2013) IF: 4.52

Fauconnier M, Palomo J, Bourigault ML, Meme S, Szemeta F, Beloeil JC, Danneels A, Charron S, Rihet P, Ryffel B, and Quesniaux VFJ. IL-12Rβ2 is essential for development of experimental cerebral malaria. J. Immunol. 188(4):1905-14 (2012) IF: 5.52

Lacerda-Queiroz N, Rodrigues DH, Vilela MC, Rachid MA, Soriani FM, Sousa LP, Campos RD, Quesniaux VFJ, Teixeira MM, Teixeira AL. Platelet-Activating Factor Receptor Is Essential for the Development of Experimental Cerebral Malaria. Am J Pathol. 180(1):246-55 (2012) IF: 4.52

Fauconnier M, Bourigault ML, Meme S, Szemeta F, Danneels A, Charron S, Fick L, Jacobs M, Beloeil JC, Ryffel B, and Quesniaux VFJ. Protein kinase C-theta is required for the development of experimental cerebral malaria. Am J Pathol. 178(1):212-21 (2011) IF: 4.89